Presented by: Rezaul Karim Ripon
View Abstract
Background: Widespread environmental contaminants known as perfluoroalkyl substances (PFAS) are associated with various harmful health effects, including cancer. For public health interventions, it is essential to understand the relationship between sources of PFAS exposure and reproductive cancer outcomes.
Objective: Using data from the 2010-2018 National Health and Nutrition Examination Survey (NHANES), investigate how PFAS exposure, which comes from sea food intake and community drinking water, is related to reproductive cancer outcomes in the US population
Methods: The study examined PFAS exposure levels among 15,015,140 participants from NHANES data from 2017 – 2018 to investigate the relationship between exposure to PFAS and cancer outcome. Demographic variables were adjusted, and regression analysis was used to evaluate the relationship.
Results: The study found that over 50% of participants were above the detection limit for PFAS which comes from seafood intake and community drinking water. AA significant association was found between exposure to PFAS in community drinking water supply sources and the incidence of prostate cancer (aOR = 1.53; 95% CI: 1.25-1.89; p < 0.001) and ovarian cancer. (aOR = 1.47; 95% CI: 1.19-1.82; p <0.001). These results highlight the increased reproductive cancer risk associated with routes of exposure to PFAS.
Conclusions: Addressing PFAS contamination in community water supplies and seafood intake as a public health priority is crucial. The strong correlation between PFAS exposure and reproductive cancer outcomes demonstrates the need for targeted interventions to reduce PFAS exposure in the population, thereby reducing the risk of cancer-related to these environmental contaminants.
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