“microbiome, to signify the ecological community of commensal, symbiotic, and pathogenic microorganisms that literally share our body space” Lederberg and McCray 2001
The Microbiome Analysis Core at the Harvard T.H. Chan School of Public Health (Microbiome Analysis Core) was established in response to the rapidly emerging field of microbiome research and its potential to affect the gamut of biomedical sciences. Its goal is to aid researchers with human microbiome study design and interpretation, reducing the gap between primary data and translatable biology.
The Microbiome Analysis Core provides a single point of contact for integrative microbiome informatics and analysis of data from amplicon (16S/18S rRNA gene and internal transcribed spacer DNA), and metagenomic and metatranscriptomic shotgun sequencing studies of the human microbiome as well as metabolomics analysis of the human microbiota. The Core has extensive experience with large metagenomic, metatranscriptomic, and individual microbial genome data collections, including bioinformatics processing of such data from large cohorts, quantitative ecology, and subsequent microbial systems analysis. By integrating data on microbial gene function and taxonomic profiles with host data, we enable researchers to interpret metabolic activities of uncultivable microbiota and assess its impact on the host.
Browse examples of the work that is done in the Microbiome Analysis Core.